The Only FDA-Approved Antithrombotic Agent for Hip Fracture Surgery

As proven in a clinical study involving over 1,700 patients undergoing hip fracture surgery, ARIXTRA significantly reduced the risks of VTE^* and proximal DVT vs enoxaparin sodium.

ARIXTRA Cut VTE by More Than Half vs Enoxaparin Sodium Following Hip Fracture Surgery

*VTE, the primary endpoint, was a composite of documented DVT and/or documented symptomatic PE reported up to day 11.

Study Characteristics

• Patient population: 1,711 patients enrolled in the study
  
• Study design: Randomized, multicenter, double-blind clinical trial in patients undergoing hip fracture surgery
• Duration of thromboprophylaxis: 5 to 9 days
• Primary efficacy outcome: VTE up to day 11, defined as DVT detected by mandatory bilateral venography, documented symptomatic DVT, or documented symptomatic PE

ARIXTRA Cut Proximal DVT^† by 79% vs Enoxaparin Sodium Following Hip Fracture Surgery

In this study, incidence of proximal DVT was 0.9% (6/650) with ARIXTRA therapy vs 4.3% (28/646) with enoxaparin sodium.

^†DVT involving popliteal or more proximal veins reported up to day 11.

ARIXTRA — An Impressive Profile of Protection Across Major Parameters in Hip Fracture Surgery

Postoperative Prophylaxis		ARIXTRA		enoxaparin		ARIXTRA Evidence-Based Conclusion
Incidence of VTE‡		8.3%		19.1%		Statistically significant (P<.001)
Proximal DVT§		0.9%		4.3%		Statistically significant (P<.001)
Safety—Major bleeding||		2.2%		2.3%		Comparable

^‡VTE, the primary endpoint, was a composite of documented DVT and/or documented symptomatic PE reported up to day 11.
^§DVT involving popliteal or more proximal veins reported up to day 11.
^||Bleeding leading to reoperation; nonfatal bleeding involving a critical organ; fatal bleeding; or bleeding index >2. Bleeding index was defined as the number of whole blood or packed red blood cell (PRBC) units transfused + [(prebleeding)-(postbleeding)] hemoglobin (g/dL) values.

Now, there is more clinical evidence in hip fracture surgery. Click here to find out more about extended prophylaxis in hip fracture surgery.

ARIXTRA — The Only Antithrombotic With FDA-Approved Indications for Hip Fracture

Click here for important safety information.

Please see full prescribing information, including BOXED WARNING for Spinal/Epidural Hematomas.